Author: mikepsinn

Potential Impact of Accelerating Research

It Feels Hopeless Problems like dementia and mental illness can seem massively overwhelming and hopeless for any one individual to make a significant impact. Billions have been spent trying to develop drugs to treat these conditions over the past several decades. However, there’s been very little progress. Indeed the prevalence of many of these diseases […]

Underlying Causes of the Increase in Neurological Disorders

Billions have been spent trying to discover pharmaceutical treatments for dementia and mental illness. However, the effort has been a near-total failure to this point. This suggests that we may benefit from looking for an underlying cause and means of prevention. Most people attribute depression and anxiety disorders primarily to life-events or genetics. Dementia is […]

What We Don’t Know is Killing Us

It was recently discovered that two types of drugs significantly increase your risk of developing dementia.  In two separate large population studies, both benzodiazepines (a category that includes medications for anxiety and sleeping pills) and anticholinergics (a group that encompasses medications for allergies and colds, depression, high blood pressure, and incontinence) were associated with an increased risk of […]

How to Measure and Compare Treatment Effectiveness

Measures of medication efficacy There’s a thousands of studies available at Absolute risk or response difference (ARD) is the risk or percentage of responders in group B subtracted from the risk or percentage of responders in group A. For example, mortality was 2 % for drug treatment and 4 % for placebo, which gives an ARD = |-2 %|. […]

Crowdsourcing Clinical Research

The Power of Crowdsourcing In the mid-1990’s Microsoft started an encyclopedia called Encarta. Microsoft invested over a billion dollars and hired hundreds of Ph.D. researchers to build up their electronic encyclopedia. In the early 2000s, Wikipedia started out with a few thousand dollars and some volunteer contributors. At the time, no one would have believed that […]

Off Label Prescriptions

Off-label prescribing has been under scrutiny since a recent study found that medications prescribed for non-FDA-approved uses are associated with a significantly higher rate of negative side effects. It is estimated that up to 20% of all medications prescribed are for indications that are not approved by the FDA.  In the study, which was published […]