FDA Sentinel Initiative

FDA Sentinel Initiative

Sentinel is the FDA’s national electronic system which has transformed the way researchers monitor the safety of FDA-regulated medical products, including drugs, vaccines, biologics, and medical devices. Sentinel has developed
Neuro-Inflammation Case Study

Neuro-Inflammation Case Study

These analyses suggest that this individual’s depression may be a manifestation of cytokine-induced interference with the conversion of tryptophan to melatonin and serotonin in conjunction with increased glutamate receptor activation.
Clinical Trial Cohort Sizes

Clinical Trial Cohort Sizes

Millions of people are prescribed medications based on efficacy trials with as few as 20 participants.
Efficacy Trials Before 1962

Efficacy Trials Before 1962

There are hundreds of conditions that a given drug may be effective at treating. However, it’s impossible to know which conditions a drug may improve until it is tried by

History of Drug Regulation

In the 1800s there was a big problem with snake oil salesmen making false claims about the concoctions they were selling. The original solution was the AMA Council on Pharmacy
Growth in Human Lifespan

Growth in Human Lifespan

For thousands of years, everything sucked and the average human life expectancy was 28. Then something happened around 1800 and life-expectancy exploded. Structural Changes Leading to the Health Explosion Let’s