Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress
Author: mikepsinn
History of Drug Regulation
In the 1800s there was a big problem with snake oil salesmen making false claims about the concoctions they were selling. The original solution was the AMA Council on Pharmacy and Chemistry certification to ethical drug products that met their standards. 1906 – Ingredient Lists and No Lying on Labels The 1906 Pure Food and […]
Growth in Human Lifespan
For thousands of years, everything sucked and the average human life expectancy was 28. Then something happened around 1800 and life-expectancy exploded. Structural Changes Leading to the Health Explosion Let’s zoom in and see what happened in the last couple of centuries leading to this explosion. We see on the timeline are two primary groups […]
Ketamine vs Esketamine Effectiveness for Depression
Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression.
Rate Ratios
Rate ratios are the ratio of the incidence rate in an exposed group divided by the incidence rate in an unexposed (or less exposed) comparison group. Consider an example from The Nurses’ Health Study. This prospective cohort study was used to investigate the effects of hormone replacement therapy (HRT) on coronary artery disease in postmenopausal […]
Identifying Causal Relationships
Validation of Methodology A technique for identifying causal relationships involves calculating the correlation between two variables use various lagging parameters when pairing data cause and effect measurements. The figure below is a demonstration of the validity of this technique that looks at the correlation between the number of minutes of cardiovascular activity and the calories […]
Depression Rates Correlate Highly with Changes in Diet and Autoimmune Disease
The increase in depression is most correlated with the increase in inflammatory autoimmune diseases and with significant changes in the western diet. The US suicide rate has increased by 40% over the last 20 years. The increase in suicides that appeared around the year 2000 correlates highly with changes in the American diet starting around […]
Data Quantity
The Foundation has collected over 10 million data points on symptom severity and influencing factors from over 10,000 people. The Foundation develops and applies predictive machine learning algorithms to the data to reveal effectiveness and side-effects of treatments and the degree to which hidden dietary and environmental improve or exacerbate chronic illnesses These analytical results have been used to freely publish 90,000 studies on […]
Macro-Level Epidemiological Data
This includes the incidence of various diseases over time combined with data on the amounts of different drugs or food additives. This is how it was initially discovered that smoking caused lung cancer. With macro-level data, it’s even harder to distinguish correlation from causation. However, different countries often enact different policies that can serve as […]
Data Sources
Individual Micro-Level Data – This could include data manually entered or imported from other devices or apps at app.crowdsourcingcures.org, This could also include shopping receipts for foods, drugs, or nutritional supplements purchased and insurance claim data. Macro-Level Epidemiological Data – This includes the incidence of various diseases over time combined with data on the amounts of different drugs […]